NUCLEIC ACID PRECURSORS AND PROTEIN SYNTHESIS

DEVELOPMENT OF THE METANEPHRIC KIDNEY Protein and Nucleic Acid Synthesis

The metanephric kidney was studied in fetal and older mice beginning at 16 days after mating of the parents. Polyribosomes from fetal kidneys labeled in vitro with 4C-labeled amino acids had 10-20 times more acid-precipitable radioactivity associated with them than polysomes from adult kidneys similarly labeled. Between 3 and 6 days after birth the rate incorporation of labeled amino acids by p...

Nucleic Acid Synthesis

INTRODUCTION Synthesis in the field of nucleic acids has been a major and continuing interest in my laboratory ever since we knew the structures of the nucleic acids. Clearly the foundations of synthetic work in the nucleotide field were laid by the prolonged and intensive efforts of Professor Todd's laboratory (Cambridge, England) and it was my good fortune to be associated with this laborator...

The Synthesis of Protein-Azobenzyl-Nucleic Acid Compounds *

Nucleic acids are found in all living cells in amounts which might appear to confer on them a r6le as structural constituents. Nucleic acids have also been associated with the activities of genes and bacterial transforming factors, particularly for the pneumococcus. The specificities of the changes mediated by them suggest strongly that the nucleic acids themselves vary in some characteristic s...

Protein–nucleic acid interactions

Nucleic acid - protein fingerprints. Novel protein classification based on nucleic acid - protein recognition

Protein chemistry uses protein description and classification based on molecular mass and isoelectric point as general features. Enzymes are also compared by enzymatic reaction constants, namely Km and kcat values. Proteins are also studied by binding to different oligonucleotides. Here we suggest a simple experimental method for such a comparison of DNA binding proteins, which we call “nucleic...